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Common names: MDPV, Bath Salts,NRG-1
Substitutive name: 3,4-Methylenedioxypyrovalerone
Systematic name: 1-(1,3-Benzodioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one
Psychoactive class: Stimulant, Entactogen
Chemical class: Cathinone

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MDPV

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3,4-Methylenedioxypyrovalerone (also known as MDPV, NRG-1, and imprecisely as Bath Salts, among many others) is a novel, extremely potent synthetic stimulant substance of the cathinone and pyrrolidine chemical classes that produces states of extreme stimulant euphoria, disinhibition, and sexual arousal when administered. MDPV is thought to act primarily as as a norepinephrine-dopamine reuptake inhibitor (NDRI) and possesses powerful euphoric stimulant qualities

MDPV, or 3,4-Methylenedioxypyrovalerone, is a synthetic stimulant belonging to the cathinone and pyrrolidine classes. MDPV is the 3,4-methylenedioxy ring-substituted analog of the compound a-PVP, developed in the 1960s, that's been being used for treating chronic fatigue and also as an anorectic, but caused problems of abuse and dependence. However, despite some shared structural features, the symptoms of MDPV bear little resemblance compared to other methylenedioxy phenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine (MDMA), instead producing primarily classical stimulant effects with simply mild entactogenic qualities

MDPV is believed to act primarily as being a potent norepinephrine-dopamine reuptake inhibitor. Reduced re-uptake of norepinephrine and dopamine results in higher concentrations of the two catecholamine neurotransmitters in the synaptic cleft, or gap between neurons. The result of this inhibition is an enhanced and prolonged concentration and resulting post-synaptic effect of dopaminergic and noradrenaline signaling at dopamine and norepinephrine receptors on the receiving neuron. Serotonin also plays a role, although to a much lesser degree. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high that MDPV provides. Mainly possessing re-uptake inhibiting qualities, MDPV could be considered more like cocaine or methylphenidate than amphetamine in method of action. In contrast, amphetamine acts primarily as an agonist to release dopamine and noradrenaline indirectly via activation of the TAAR1 receptor.

*Subjective effects
The effects listed below are based upon the subjective effects index and personalThe listed effects will rarely (if ever) occur rapidly, but heavier dosages will increase the chances and are therefore more likely to induce a full range of effects.

*Physical effects
-Abnormal heartbeat
-Appetite suppression
-Diarrhea or nausea - Some experience reports describe individuals who have experienced one or more types of gastrointestinal disturbance while under the influence of MDPV.
-Gustatory hallucinations
-Headaches
-Increased heart rate - Higher doses of MDPV can create a significant and often dangerous increase in heart rate and blood pressure.
-Muscle contractions
-Muscle spasms
-Restless leg syndrome
-Stamina enhancement
-Stimulation

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*Cognitive effects
The general cognitive effects of MDPV can be described as being similar to those of other typical stimulants. At common dosages, the MDPV high is described as being euphoric and slightly empatheogenic in its effects, causing increased motivation, sociability, sexual desire and concentration. Higher doses of MDPV, however, can intensify numerous negative effects such as anxiety and disorganized thoughts; at extremely high doses or continued use, delusions and psychosis become likely.

*Anxiety
-Cognitive euphoria
-Compulsive redosing - MDPV is extremely potent in this effect; it been shown to sometimes cause users to redose even without planning to do so.
-Confusion - This effect is intensified at higher doses.
-Creativity enhancement
-Delusions - This effect can also manifest with high doses.
-Ego inflation
-Empathy, love, and sociability enhancement - MDPV's effects in this regard are similar to, but weaker than, those of MDMA.
-Focus enhancement
-Increased libido
-Motivation enhancement
-Paranoia
-Stamina enhancement
-Psychosis - High doses of MDPV have been known to induce states of psychosis at a more frequent rate than most other stimulants.[citation needed]
-Time distortion - This can be described as the experience of time speeding up and passing much quicker than it usually would when sober.
-Thought acceleration
-Thought organization - Mainly observed with low to common doses.
-Thought disorganization - This effect manifests and is also intensified with higher doses.
-Wakefulness

*After effects
The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:

*Anxiety
-Cognitive fatigue
-Depression
-Irritability
-Motivation suppression
-Thought deceleration
-Wakefulness

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2017-10-13

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2017-10-13

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